Abstract
Micro/nanostructures, which are assembled from various nanosized building blocks are of great scientific interests due to their combined features in the micro- and nanometer scale. This study for the first time demonstrates that ultrasmall superparamagnetic iron oxide nanoparticles can change the microstructure of their hydrocolloids under the action of external magnetic field. We aimed also at the establishment of the physiological temperature (39 °C) influence on the self-organization of silver and ultrasmall iron oxides nanoparticles (NPs) in hydrocolloids. Consequences of such induced changes were further investigated in terms of their potential effect on the biological activity in vitro. Physicochemical characterization included X-ray diffraction (XRD), optical microscopies (SEM, cryo-SEM, TEM, fluorescence), dynamic light scattering (DLS) techniques, energy dispersive (EDS), Fourier transform infrared (FTIR) and ultraviolet–visible (UV-Vis) spectroscopies, zeta-potential and magnetic measurements. The results showed that magnetic field affected the hydrocolloids microstructure uniformity, fluorescence properties and photodynamic activity. Likewise, increased temperature caused changes in NPs hydrodynamic size distribution and in hydrocolloids microstructure. Magnetic field significantly improved photodynamic activity that was attributed to enhanced generation of reactive oxygen species due to reorganization of the microstructure.
Highlights
Micro/nanostructures, which are assembled from various nanosized building blocks are of great scientific interests due to their combined features in the micro- and nanometer scale
In this study we investigated the influence of external magnetic field on the self-organization process of the mixture of silver and ultrasmall iron oxide (MAg) NPs, namely, on their microstructure, fluorescent and electrical properties
Self-organizing MAg and ultrasmall iron oxide (USIO) NPs were synthesized by co-precipitation technique using ginger extract as a capping agent
Summary
Micro/nanostructures, which are assembled from various nanosized building blocks are of great scientific interests due to their combined features in the micro- and nanometer scale. We aimed at the establishment of the physiological temperature (39 °C) influence on the self-organization of silver and ultrasmall iron oxides nanoparticles (NPs) in hydrocolloids Consequences of such induced changes were further investigated in terms of their potential effect on the biological activity in vitro. The researchers’ interest is moving from “single” nanoparticles (NPs) to micro/nanostructures that can be formed due to the ability of NPs to self-organize This direction in the evolution of nanotechnology appeared simultaneously in different fields of nanoscience, exemplified by self-organizing polymers and metal oxides, three dimensional (3D) graphene architectures and metamaterials. The influence of their self-organizing microstructure on biomedical interactions has not been studied so far The properties of such micro/nanosystems might be quite different from those composed of unstructured NPs and may lead to unexpected results. Such a combination is expected to exhibit high potential for biomedicine, in particular as a multimodal material with therapeutic and optical imaging abilities
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