Abstract
• 5 ns pulses cause diverse patterns of Ca 2+ release from the ER of chromaffin cells. • Patterns include a single Ca 2+ transient or multiple Ca 2+ spikes. • IP 3 - and caffeine-sensitive ER Ca 2+ stores are differentially involved. • Ca 2+ release due to membrane poration occurs from caffeine-sensitive stores. • Ca 2+ spikes are associated with Ca 2+ release mediated by IP 3 receptors.
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