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Abstract
This chapter focuses on the ultrashort feedback effects of releasing hormones. Previous experiments had indicated that the subcutaneous administration of crude hypothalamic extracts containing follicle-stimulating hormone–releasing hormone (FSH-RH) and devoided of any FSH and sex steroid contamination may bring about a significant reduction of FSH-RH stores in the hypothalamus of castrated, hypophysectomized rats. These experiments suggested the possibility that the brain might contain receptors sensitive to circulating levels of FSH-RH, and that FSH-RH might directly regulate its own production via an “ultrashort” feedback effect. imilar experiments have now been repeated using synthetic LH-RH and its effects have been evaluated on hypothalamic LH-RH stores of castrated, hypophysectomized male rats. LH-RH contained in the hypothalamus has been evaluated injecting hypothalamic extracts into the carotid artery of castrated estrogen-pretreated female rats and measuring the rise of radioimmunoassayable LH in their serum.
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