Ultrashort Echo Time Quantitative Susceptibility Mapping (UTE-QSM) of Highly Concentrated Magnetic Nanoparticles: A Comparison Study about Different Sampling Strategies.

Xing Lu,Yajun Ma,Eric Y Chang,Eric Y Chang,Saeed Jerban,Hyungseok Jang,Jiang Du

doi:10.3390/molecules24061143

Abstract

The ability to accurately and non-invasively quantify highly concentrated magnetic nanoparticles (MNPs) is desirable for many emerging applications. Ultrashort echo time quantitative susceptibility mapping (UTE-QSM) has demonstrated the capability to detect high iron concentrations. In this study, we aimed to investigate the effect of different sampling trajectories on the accuracy of quantification based on MNPs acquired through UTE-QSM. A phantom with six different MNP concentrations was prepared for UTE-QSM study with different UTE sampling trajectories, including radial acquisition, continuous single point imaging (CSPI), and Cones with four different gradient stretching factors of 1.0, 1.2, 1.4, and 1.6. No significant differences were found in QSM values derived from the different UTE sampling strategies, suggesting that the UTE-QSM technique could be accelerated with extended Cones sampling.

Highlights

In the past ten years, magnetic nanoparticles (MNPs) have been used in many medical branches, such as cell labeling, drug delivery, magnetic resonance imaging (MRI), and magnetic hyperthermia for cancer therapy [1,2]
Tumors can be destroyed with minimal harm to healthy tissues, reducing the negative side effects associated with the delivery of drugs
We aimed to investigate the effect of different ultrashort echo time (UTE) sampling strategies on the Quantitative susceptibility mapping (QSM)-based evaluation of MNPs concentration

Summary

Introduction

In the past ten years, magnetic nanoparticles (MNPs) have been used in many medical branches, such as cell labeling, drug delivery, magnetic resonance imaging (MRI), and magnetic hyperthermia for cancer therapy [1,2]. To initiate cell necrosis/coagulation/carbonization for tumor destruction [4] With this approach, tumors can be destroyed with minimal harm to healthy tissues, reducing the negative side effects associated with the delivery of drugs. Tumors can be destroyed with minimal harm to healthy tissues, reducing the negative side effects associated with the delivery of drugs In this way of cancer therapy, MNPs are injected directly into the tumor; an external alternating magnetic field with a specific frequency between 50 kHz to. The ability to accurately and non-invasively quantify highly concentrated MNPs is closely related to the rapidly growing area of magnetic biosensing [7,8,9]

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Conclusion