Abstract
We report the fabrication and characterization of a highly sensitive pressure sensor that has been successfully tested using 3D-bioprinted skeletal muscle tissue. The proposed pressure sensor consists of two assembled 3D printed specimens, which were obtained using 60/40 v/v poly(3,4-ethylenedioxythiophene):polystyrene sulfonic acid (PEDOT:PSS) / poly(ethylene glycol) diacrylate (PEGDA) mixture, placed between two indium tin oxide-coated polyethylene terephthalate (PET-ITO) films. The printed specimens were shaped with a serrated structure, improving the sensitivity of the contact when pressed against PET-ITO film. Initially, the performance of the fabricated pressure sensor was tested using light cylindrical weights, which corresponded to pressures ranging from 0.99 to 14.71 kPa, and as prove of concept, carefully pressing with the finger (from 2.91 to 6.81 kPa). As the sensitivity and fast response of sensor were compatible with detection of soft muscle contractions, 3D-bioprinted skeletal muscle bioactuators were manufactured using myoblast cells. The contractions of the bioactuators, which were induced using electrical stimulation, exerted a pressure of 1.5 kPa only that was clearly and precisely detected by the sensor. Overall, the potential application of proposed pressure sensor for wearable and biomedical devices is evidenced by demonstrating its fast response time (< 50 ms) and sensitivity.
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