Abstract
Abstract We present the development of an ultrasensitive electrochemical sensor for detecting paracetamol, utilizing nanomaterial modified electrode. Cobalt oxide (Co₃O₄) nanoparticles were synthesized via a hydrothermal method using cobalt (II) nitrate hexahydrate. This was followed by the polymerization of pyrrole with ferric chloride serving as the oxidizing agent. Equal ratios of polypyrrole (PPy) and Co₃O₄ were then subjected to sonication. The structural and compositional characteristics of the resulting nanocomposite were analyzed using various techniques. XRD confirmed the crystalline structure of the PPy/Co₃O₄ composite, while UV-Vis spectroscopy identified distinct absorption peaks corresponding to both PPy and Co₃O₄. FT-IR analysis revealed specific functional groups present in the nanocomposite, and FE-SEM provided visual confirmation of the successful integration of PPy and Co₃O₄. Additionally, EDAX offered insights into the elemental composition of the composite. Cyclic voltammetry showed that the PPy/Co₃O₄ modified electrode generated significantly enhanced current responses and well-defined redox peaks compared to the individual components. The PPy/Co₃O₄ modified sensor demonstrated excellent stability, high catalytic current for paracetamol (200 µM), highlighting its increased sensitivity and selectivity. This new sensor showed a detection limit of 0.49 µM and supported a linear detection range from 0 µM to 200 µM, allowing for precise quantification of paracetamol concentrations.
Accepted Version
Published Version
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