Abstract
Ultra fast separation of large biomolecules is always a challenge for chemists because of slow mass transfer rate of large biomolecules. Superficially porous reversed-phase HPLC packings have taken their place in the scientific toolkit as the optimum particle for ultra-fast separations of proteins and polypeptides [1]. Versatility in this arena has been increased due to the development of sterically protected C18, C8 and C3 bonded phases for low pH application and bidentate C18 for high pH application. The new column formats such as capillary HPLC column not only increase the speed of the separation, but also dramatically increase the sensitivity of the separation.
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