Abstract

The purpose of this research is to compare the diagnostic results of basic ultrasound-guided needle biopsy (USCNB) versus biopsy-guided biopsy for suspicious microscopic calcifications and to assess the usefulness of USCNB in diagnosing microscopic calcifications by comparing histological results according to the results whether or not lesions exist on Ultrasound. Retrospectively, we reviewed 178 cases of suspected partial calcification of mammography without a specific mass in 158 patients underwent biopsy-guided images. Patients with US-CNB (n = 47) and ultrasound-guided biopsy (US-LEB) (n = 72), and those with invisible lesions in the United States underwent an X-ray biopsy (MG-LEB) (n = 32) and vacuum-assisted biopsy (S-VAB) (n = 27). The results of x-ray mammography were analyzed and false negative rates were evaluated. Histological diagnosis, breast imaging reports and Data Classification System (BI-RADS) were evaluated. Of all lesions, 119 of 178 (66.9%) were visible to the United States. US vision was more frequently associated with malignant tumors (27.7% vs. 11.9%, P = 0.012) and with the highest BI-RADS category (32.8% vs.15.3%, P = 0.019). The overall false negative rate was 10.0% (4/40). Three of the four erroneous negative outcomes occurred in US-CNB and 1 in SVAB. The frequency of the malignant tumor was significantly higher in the visible microscopic calcifications in the United States that were within a cluster or associated with duct dilatation (72.7% vs. 17.5%, P <0.001). Micro-visible calcifications of the United States were associated with a higher BI-RADS class and higher malignancy rate versus invisible lesions in the United States.

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