Abstract
Chemical investigation of Ulmus wallichiana stem bark resulted in isolation and identification of three new compounds (2 S,3 S)-(+)-3′,4′,5,7-tetrahydroxydihydroflavonol-6- C-β- d-glucopyranoside ( 1), (2S,3S)-(+)-4′,5,7-trihydroxydihydroflavonol-6- C-β- d-glucopyranoside ( 3) and 3- C-β- d-glucopyranoside-2,4,6-trihydroxymethylbenzoate ( 8), together with five known flavonoid-6-C-glucosides ( 2, 4– 7). Their structures were elucidated using 1D and 2D NMR spectroscopic analysis. The absolute stereochemistry in compounds 1 and 3 were established with the help of CD data analysis and comparison with the literature data analysis. All the isolated compounds ( 1– 8) were assessed for promoting the osteoblast differentiation using primary culture of rat osteoblast as an in vitro system. Compounds 1– 3 and 5 significantly increased osteoblast differentiation as assessed by alkaline phosphatase activity.
Published Version
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