Uji Aktivitas Antidiabetes Ekstrak Bonggol Nanas (Ananas comusus L.) pada Tikus yang Di induksi Aloksan

Abstract

This research aims to knowing about decrease glucose levels in rat induced alloxan with the provision of pineapple stem extract (Ananas comusus L.). Previous studies have shown that bromelin can significantly reduce CD4+ lymphocytes, which are included in inflammatory diseases. One of the inflammatory diseases is diabetes mellitus. Blood glucose levels can be lowered by pineapple extract as it contains bromelin, and bromelin most widely found on the stem. The test animals used white rat strain wistar (Rattus norvegicus L.) with weight is 250-300 gram acclimated for seven days. The research was divided six treatment groups: positive control, negative control, P1 (25% concentration), P2 (50% concentration), P3 (75% concentration), P4 (100% concentration). After treatment for rat in category or sampel was administered pineapple stem extract for 14 days after that experiment status blood glucose level. The results showed that rat had increased (hyperglicemic) after alloxan induced,and also in blood glucose levels in all treatment. the biggest decrease was in P4 is 44 mgdl. The statistic of Kruskal-Wallis test showed that the decrease of rat blood glucose concentration at various concentration of pineapple extract influence signifificantly. According to the result that conclusion is the difference of pineapple extract concentration (25%, 50%, 75%, 100%) influence for decrease blood glucose levels and decreasing blood glucose level after 14 days, but in this time blood glucose not returned as normal conditions.