The effect of perennial sow-thistle (Sonchus arvensis) leaf extract on blood glucose and plasma insulin levels of diabetic mice

Abstract

Abstract. Haryta FS, Listyawati S, Pangastuti A. 2021. The effect of perennial sow-thistle (Sonchus arvensis) leaf extract on blood glucose and plasma insulin levels of diabetic mice. Cell Biol Dev 5: 63-69. The prevalence of diabetes mellitus (DM) has recently increased, thus encouraging drug exploration, especially from natural compounds. One of the potential medicinal plants to reduce blood glucose levels in people with diabetes mellitus is perennial sow-thistle (Sonchus arvensis). This study was conducted to determine the effect of perennial S. arvensis leaf extract on mice's blood glucose levels and plasma insulin levels induced by streptozotocin. This study used six treatment groups, namely: normal, positive control (acarbose 0.13 mg/20ggBW), negative control (aquadest), and treatment group of perennial S. arvensis leaf extract at doses of 50 mg/kgBW, 100 mg/kgBW, and 150 mg/kgBW. The treatments were done by oral administration daily for 14 days. Measurements of blood glucose levels and postprandial plasma insulin levels were measured at 0, 60, and 120 minutes. The test animals were monitored for 14 days, and fasting blood glucose levels were measured on the 7th and 14th days. Data analysis using one-way ANOVA, and if there is a significant difference, it is continued with Duncan's Range Test (DMRT). The results showed that perennial S. arvensis leaf extract could reduce postprandial blood glucose elevation and blood glucose levels in diabetic mice, which were monitored for 14 days. The most effective dose is 150 mg/kgBW. Perennial S. arvensis leaf extract increased postprandial plasma insulin levels at 60 minutes; the most effective dose is 50 mg/kgBW.