Abstract
Malaria disease is still a serious health problem in Indonesia. This study aimed to determine the antimalarial activity of triterpenoid compound fraction of A. camansi leaf methanol extract to P. berghei of in vivo. This experiment of using research a completely randomize design (CRD) with four different doses (0.1 mg/kg BW, 1 mg/kg BW, 10 mg/kg BW, 100 mg/kg BW) and one negative control group (1 % CMC). The results show that triterpenoid compound fraction of A. camansi leaf methanol extract was effective to reduce parasite activity of P. berghei . The most effective dose was 100 mg/kg BW for three days with daily treatment after the mice was infected by parasite.
Highlights
The results show that triterpenoid compound fraction of A. camansi leaf methanol extract was effective to reduce parasite activity of P. berghei
(2012), Antimalarial activity of hexane extract of neem leaves
Summary
Mahasiswa Program Studi Magister Pendidikan IPA, Program Pascasarjana, Universitas Mataram. Penyakit malaria merupakan masalah kesehatan yang serius di Indonesia. Penelitian ini bertujuan untuk mengetahui aktivitas antimalaria fraksi senyawa triterpenoid dari ekstrak methanol daun A. camansi terhadap P. berghei secara in vivo. Lengkap (RAL) dengan empat kelompok dosis yang berbeda (0,1 mg/kg BB, 1 mg/kg BB, 10 mg/kg BB, dan 100 mg/kg BB) dan satu kelompok kontrol (CMC 1 %). Tiap kelompok perlakuan terdiri dari lima ekor mencit. Hasil penelitian menunjukkan bahwa fraksi senyawa triterpenoid dari ekstrak metanol daun. A. camansi berpengaruh terhadap aktivitas antimalaria P. berghei. 100 mg/kg BB selama tiga hari dengan waktu pemberian sehari setelah mencit terinfeksi parasit
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