Učestalost različitih tipova sindroma iritabilnog kolona kod pacijenata sa nealkoholnom masnom jetrom

Abstract

Introduction: Non-alcoholic fatty liver (NAFLD) is an excessive accumulation of fat, detected by imaging methods or histologically, in people who haven't consumed alcohol, associated with insulin resistance and metabolic syndrome. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, diagnosed by Rome IV criteria, with no morphological disorders in the digestive system. Aim: Detecting frequency between different types of IBS in different grades of steatosis to distinguish possible association between the two diseases. Material and methods: In retrospective study at the Clinic for Gastroenterohepatology of the University Clinical Center of Serbia, from January to June 2020, a number of 49 patients over 18 years were diagnosed with NAFLD and IBS. Based on the ultrasound examination, patients are classified into those with grades I, II and III of steatosis, and according to the Roma IV criteria, into IBS-C, IBS-D and IBS-M type. Body Mass Index (BMI), hyperglycemia, cholesterol, triglycerides, ALT, AST, gGT, Diabetes Mellitus (DM), arterial hypertension, Gastroesophageal Reflux Disease (GERD) and cholelithiasis are examinated. Results: In retrospective study at the Clinic for Gastroenterohepatology of the University Clinical Center of Serbia, from January to June 2020, a number of 49 patients over 18 years were diagnosed with NAFLD and IBS. Based on the ultrasound examination, patients are classified into those with grades I, II and III of steatosis, and according to the Roma IV criteria, into IBS-C, IBS-D and IBS-M type. Body Mass Index (BMI), hyperglycemia, cholesterol, triglycerides, ALT, AST, gGT, Diabetes Mellitus (DM), arterial hypertension, Gastroesophageal Reflux Disease (GERD) and cholelithiasis are examinated. Conclusion: Patients with NAFLD and IBS are predominantly female. Non-alcoholic fatty liver is associated with metabolic syndrome, insulin resistance, GERD, and cholelithiasis. No association was shown between the grade of steatosis and the type of IBS, except in cholesterol, with the highest frequency in grade III of steatosis and the IBS-C type.