Tyrosinase and α-Glucosidase Inhibitory Effects of an Abietane Type Diterpenoid Taxodone from Metasequoia glyptostroboides

Abstract

In this study, a diterpenoid compound taxodone, isolated from Metasequoia glyptostroboides was evaluated for tyrosinase and α-glucosidase inhibitory effects in terms of its potent anti-melanogenesis and anti-diabetic potential, respectively. As a result, taxodone at the concentration range of 200–1,000 and 100–3,000 µg/ml showed potent efficacy on inhibiting tyrosinase and α-glucosidase enzymes in vitro by 11.08–49.32 and 10.11–50.62 %, respectively. These findings confirm the therapeutic potential of diterpenoid compound taxodone from M. glyptostroboides as a novel candidate for using in food and medicine industry with a potential of skin whiting agent and to treat diabetes mellitus type II related disorders.