Abstract
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common chronic immune-mediated demyelinating neuropathy and includes several clinical subtypes. The major phenotype is "typical CIDP," which is characterized by symmetric polyneuropathy and "proximal and distal" muscle weakness. In typical CIDP, the nerve roots and distal nerve terminals, where the blood-nerve barrier is anatomically deficient, are preferentially affected, and therefore antibody-mediated immune pathogenesis is likely to have a major role. Currently, CIDP is considered a syndrome including typical CIDP and CIDP variants. In 2021, the European Academy of Neurology/Peripheral Nerve Society Guideline was published, whereas the Japanese CIDP/ Multifocal Motor Neuropathy Clinical Practice Guideline will be available in May 2024. This review article summarizes the immunopathogenesis, diagnosis, and treatment for typical CIDP.
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