Type of Fracture Is an Independent Determinant of Long-Term Mortality in Older Patients With Hip Fracture: Systematic Review and Meta-Analysis of Longitudinal Studies

Abstract

s 423 Results: In our study group, mean age was 61.1 11.7 years and mean BMI was 27.9 5.3 kg/m. At the time of baseline DXA scan, women with incident fracture (n5164) were shorter (1.527 0.065 m vs. 1.560 0.078 m; P!0.001), were older (65.0 11.5 years vs. 60.4 11.6 years; P!0.001), had a higher BMI (29.4 5.3 kg/m vs. 27.6 5.3 kg/m; P!0,001), had a lower femoral neck BMD (0.736 0.120 g/cm vs. 0.796 0.158 g/cm; P!0.001) and had a lower FN CSI (3.55 0.74 g/kg m vs. 3.88 0.81 g/kg m; P!0.001) than women without fracture (n5836). Body weight was not significantly different between women with incident fracture and women without simple logistic regression (odds ratio [95%CI]50.51 [0.385-0.653]). Femoral neck BMD was significantly (P!0.001) associated with the presence of fracture using a simple logistic regression (odds ratio [95%CI]50.041 [0.011-0.152]). Age, height and BMI were also significantly associated with the presence of fracture using simple logistic regressions (P! 0.001). When a multivariate logistic regression analysis was performed with the presence of fracture as a dependent variable and each age, FN BMD and FN CSI as independent variables, only FN BMD (P50.005) and FN CSI (P50.004) were found to be associated with the presence of fracture. Conclusion: This study suggests that FN CSI is an independent predictor of osteoporotic fractures in postmenopausal women. Further research is needed to determine the relative importance of FN CSI on fracture risk prediction in postmenopausal women.