Abstract
The pathogenicity of herpes simplex virus (HSV) in primary cultures of epithelial, stromal, and endothelial cells of rabbit corneas was studied at various incubation temperatures (30°, 36°, and 40°C). We tested three strains each of type 1 (HSV-1) and type 2 (HSV-2). At all three temperatures, the epithelial cells appeared to be more susceptible to both HSV-1 and HSV-2 than the stromal and endothelial cells. In general, less HSV-1 was required than HSV-2 to infect the same type of corneal cell at the same incubation temperature. At 40°C, however, there was far less cell destruction by either HSV-1 or HSV-2 than at 30° or 36°C. This inhibition at 40°C was more pronounced in the cells infected with HSV-2 than in those infected with HSV-1, and the inhibition was accompanied consistently by significant suppression of virus multiplication in the cells.
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