Two year remission rates and functional outcomes in an inception cohort of Canadian children with juvenile idiopathic arthritis

Shirley Ml Tse,Jaime Guzman,Lori B Tucker,Rae Sm Yeung,Kiem G Oen,Kim Morishita,Ciaran M Duffy,Rosie Scuccimarri,Gaelle Chédeville,Janet E Ellsworth,Natalie J Shiff

doi:10.1186/1546-0096-10-s1-a60

Abstract

Purpose To examine the remission rates and functional outcomes in an inception cohort of patients with juvenile idiopathic arthritis (JIA). Methods The Research in Arthritis in Canadian Children, emphasizing Outcomes (ReACCh-Out) cohort is a 16-centre inception cohort of patients with JIA enrolled within 1 year of diagnosis. All patients who completed 5 sixmonthly study visits from baseline to 24 months were included in this analysis. Disease activity and functional measures were collected at each visit. Criteria for disease remission status in this study were defined by Wallace et al (2006) modified by omission of ESR or CRP due to incomplete data. Inactive disease (ID) was defined as no active joints, physician global assessment 0, and no active extra-articular disease; clinical remission on medications (CRM) is ID for ≥ 6 months on medications; and clinical remission (CR) is ID for ≥ 12 months off medications. Health status was measured using the Juvenile Arthritis Quality of Life Questionnaire (JAQQ), and functional status using the Child Health Assessment Questionnaire (CHAQ). Results

Highlights

To examine the remission rates and functional outcomes in an inception cohort of patients with juvenile idiopathic arthritis (JIA)
The percentage of patients with Inactive disease (ID) was 33% at 6 months, 39% at 12 months and 49% at 24 months; clinical remission on medications (CRM) increased from 4% at 6 months to 18% at 12 months and 26% at 24 months, while clinical remission (CR) at 24 months was 7%
Differences in remission rates were evident amongst the JIA subtypes by 12 months, with the highest remission rates in oligoarthritis and lowest in the RF positive polyarthritis (CRM of 29% and 4% respectively)

Summary

Open Access

Shirley ML Tse5*, Lori B Tucker, Gaelle Chédeville, Janet E Ellsworth, Jaime Guzman, Kim Morishita, Rosie Scuccimarri, Natalie J Shiff, Ciaran M Duffy, Rae SM Yeung, Kiem G Oen. From 2011 Pediatric Rheumatology Symposium sponsored by the American College of Rheumatology Miami, FL, USA. Purpose To examine the remission rates and functional outcomes in an inception cohort of patients with juvenile idiopathic arthritis (JIA)

Methods

Results

Conclusion