Abstract
Background. Mantidis Ootheca (MO), described as the ootheca of Hierodula patellifera Serville, 1839, Tenodera angustipennis (Saussure, 1869), or Statilia maculate (Thunberg, 1784) in Korean Herbal Pharmacopoeia, is an important herbal material that has been traditionally used for treating several medical conditions including renal failure, spermatorrhea, and pediatric enuresis in Korea. Objective. The present study investigated the potential subacute toxicity of MO water extract during a 2-week repeated oral administration of doses of 0, 50, 150, or 450 mg/kg/day to C57BL/6 male mice by gavage. Methods. The following parameters were examined during the study period: mortality, clinical signs, body weight, hematology, serum biochemistry, gross findings, organ weight, and histopathology. All the mice were euthanized at the end of the treatment period. Results. No treatment-related changes in mortalities, clinical signs, body weight, gross finding, and organ weight change were detected after 14 days of oral MO extract administration. In addition, no meaningful MO extract treatment-related changes were observed in the hematological, serum biochemical, and histopathological parameters compared with the normal control group following treatment with doses of up to 450 mg/kg/day. Conclusion. Based on these findings, we concluded that treatment of mice with the water extract of MO did not result in significant toxicity and, therefore, it could be considered safe for further pharmacological studies.
Highlights
Insects have been commonly used as a source of food and drug resources worldwide [1]
We did not observe any mortality in mice administered the oral extract of Mantidis Ootheca (MO) during the 2-week study period (Table 1)
Mice treated with the MO extract at 50, 150, and 450 mg/kg/day did not show mortality and clinical signs throughout the study, similar to the control group. These findings indicate that oral administration of repeated doses of the MO extract did not exert any toxicity on the growth and function of mice
Summary
Insects have been commonly used as a source of food and drug resources worldwide [1]. The focus of drug-related research has shifted to insect-based products with a potential to be used as medicines to treat a variety of diseases. In this regard, several insect varieties to species have been tested by pharmaceutical companies as potential sources of modern drugs [5]. No treatment-related changes in mortalities, clinical signs, body weight, gross finding, and organ weight change were detected after 14 days of oral MO extract administration. Based on these findings, we concluded that treatment of mice with the water extract of MO did not result in significant toxicity and, it could be considered safe for further pharmacological studies
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