Abstract
Electron diffraction intensity data from epitaxially crystallized samples of 1,2- dihexadecyl-sn- glycero-3- phospho-N- methylethanolamine are used to determine the lamellar packings of two polymorphic forms. One form is a typical bilayer structure, with untilted acyl chains packing in the hexagonal methylene subcell and resembles the structures of dihexadecylphosphatidylethanolamine (DHPE) and -choline (DHPC). The lamellar spacing is very close to that of DHPC, indicating that the initial methylation in itself causes a dramatic change in the bilayer thickness. The second polymorph is an interdigitated structure, again with untilted chains which pack in the orthorhombic perpendicular subcell. Direct electron microscope lattice images have been obtained from both crystal forms at low beam does to justify the correction of observed electron diffraction intensities for curvilinear lamellar distortions. The use of such image data for phasing low angle diffraction data is also successful.
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