Two transition metal coordination polymers: treatment effect against the CVB3 induced viral myocarditis through inhibiting the NF-κB signaling pathway

Abstract

Via applying the mixed-ligand approach, two new transition metal coordination polymers (CPs), namely, [Zn2(OH)(TZI)(2,2′-bpy)]·2H2O (1) and [Co2(OH)(TZI)(4,4′-bpy)0.5] (2) (H3TZI = 5-(4-(tetrazol-5-yl)phenyl)isophthalic acid, 2,2′-bpy = 2,2′-bipyridine, 4,4′-bpy = 4,4′-bipyridine), have been synthesized under hydrothermal conditions via using a bifunctional organic ligand H3TZI. Its treatment effect on the CVB3 induced viral myocarditis in vivo was evaluated and the specific mechanism was explored at the same time. First of all, the content of the creatine kinase (CK-MB) in the myocardial cells was determined with Creatine Kinase detection kit. In addition to this, the relative expression level of the NF-κB signaling pathway in myocardial cells after treatment was assessed with real time reverse transcription-polymerase chain reaction (RT-PCR).