Abstract
Two new transition metal coordination polymers (CPs), namely, [Co2(OH)(TZI)(DMA)] (1) and [Mn2(OH)(TZI)(H2O)2] (2) have been synthesized under solvo-/hydrothermal conditions via using a bifunctional organic ligand 5-(1H-tetrazol-5-yl)isophthalic acid (H3TZI). Their treatment activity on the renal ischemia-reperfusion injury was evaluated and the related mechanism was explored at the same time. The ELISA detection kit was conducted to measure the levels of the inflammatory cytokines IL-1β and TNF-α released by the epithelial cells in distal tubules. In addition to this, the HE staining was further conducted to confirm the pathological damage levels in the kidney tissue.
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