Two simple spectrophotometric methods for the simultaneous determination of benzocaine and phenazone

Abstract

Simple, specific, accurate and precise spectrophotometric methods were developed and validated for simultaneous estimation of Benzocaine and Phenazonein their pure form and pharmaceutical dosage form. Two spectrophotometric methods were applied: derivative ratio spectra and absorbance ratio method. The linearity range for the spectrophotometric methods was found to be (0.3–30μg/mL) and (0.7–30μg/mL) for benzocaine and phenazone respectively in derivative ratio method and to be (0.5–27μg/mL) and (0.7–30μg/mL) for benzocaine and phenazone respectively in absorbance ratio method. Both methods were simple, sensitive, ecofriendly and don't need a special program, so they could be easily applied as alternative methods to LC methods in quality control laboratories lacking the required facilities for those techniques.