Abstract
Dioscoresides A and B were isolated from the rhizomes of Dioscorea panthaica and shown to possess a novel furostanol skeleton. Their structures were fully elucidated as 3- O-[β- d-glucopyranosyl-(1→3)- O-α- l-rhamnopyranosyl-(1→2)-β- d-glucopyranosyl]-26- O-β-20, 22- seco- d-glucopyranosyl-25 ( R)-furosta-5-en-20, 22-dione-3β, 26-diol and 3- O-[bis-α- l-rhamnopyranosyl-(1→4 and 1→2)-β- d-glucopyranosyl]-26- O-β- d-glucopyranosyl-20, 22- seco-25 ( R)-furosta-5-en-20, 22-dione-3β, 23( S), 26-triol by spectroscopic techniques and chemical means. These compounds exhibited cytotoxic activity tested in vitro on A375-S2, L929 and Hela cell lines.
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