Two novel eremophilane sesquiterpenes from an endophytic Xylariaceous fungus isolated from leaves of Cupressus lusitanica

Abstract

Dois novos sesquiterpenos eremofilanos, cupressolideo A e cupressolideo B, alem de dois outros conhecidos, foram isolados a partir do extrato AcOEt do meio de cultura de uma especie de Xylaria, isolada como fungo endofitico dos tecidos sadios das folhas de Cupressus lusitanica. Estudos espectroscopicos, usando EM e RMN, levaram as estruturas dos dois sesquiterpenos de esqueleto eremofilanos, novos na literatura. Two new eremophilane sesquiterpenes, cupressolide A and cupressolide B, along with two known sesquiterpenes, has been characterized from the EtOAc extract of a liquid medium where a Xylariaceous fungus, isolated as an endophytic fungus from health tissues of Cupressus lusitanica leaves, was cultivated. The structures of the isolated compounds were determined by analyses of their MS and NMR spectroscopic data.