Abstract
Two coordination polymers, that is [Zn(pdc)(im)(H2O)]n (1) and [Cu(pdc)(im)2]n·n(H2pdc) (2) (H2pdc = terephthalic acid, im = imidazole), were hydrothermally synthesized via the reactions of H2pdc and im in combination with Zn(II) or Cu(II) ions. Compound 1 shows intense blue luminescence and compound 2 shows good photocatalytic activity for the methyl violet degradation under the irradiation of ultraviolet light. In addition, the assessment of the two compounds' application values against Parkinson's disease were carried out and their specific mechanism was tested simultaneously. First of all, the real time RT-PCR was implemented and the relative expression levels of N-methyl-D-aspartic acid receptor receptor on neurons were measured. Besides, the Annexin V-FITC/PI apoptosis assay was utilized for the assessment of the influence of the compounds on the dopaminergic neuron death rate. The hemolysis toxicity detection was conducted to detect the biocompatible of the compounds.
Highlights
Parkinson's disease (PD) is a type of common neurodegenerative disease in the middle-aged people and elderly
Coordination polymers with novel compositions and topological frameworks have attracted great attention mainly owing to their functional properties that make them can be served as potential hybrid materials in catalysis, luminescence, magnetism, gas separation and storage, and other areas [4,5,6,7]
These tetrahedral Zn(II) ions are linked through the ligands of pdc2− by the carboxylic acid groups with the uniform monodentate manner to provide an one-dimensional infinite zigzag chain architecture (Fig. 1b), and the Zn...Zn separated by pdc2− ligand is 11.01 Å
Summary
Parkinson's disease (PD) is a type of common neurodegenerative disease in the middle-aged people and elderly. The syntheses, crystal structures, thermal behaviors, luminescent and photocatalytic properties will be reported Their treatment effect on the PD was explored and the relevant mechanism was explored. It was gradually cooled to ambient temperature, the 2’s blue massive crystals were acquired with 52 percent yield according to Cu(NO3)2·3H2O. The real time RT-PCR was finished to determine the expression levels of NMDA receptor on the neurons after the treatment of compounds. This conduction was implemented completely in accordance with instructions with only minor modification. The study requires to be finished at least 3 times
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