Abstract
Pseudolarolides U and V, two new triterpenoids, and four biogenetically related compounds, pseudolarolides E, F, K, and P were isolated from the roots of Codonopsis pilosula (Campanulaceae). Their structures were determined by spectroscopic data. The regulation of Sirtuin 1 (SIRT1) activity by all the isolated compounds was evaluated.
Highlights
The root of Codonopsis pilosula, known as “Dangshen” in Chinese, has been used in traditionalChinese medicine to treat “qi” deficiency, improve appetite, and strengthen the immune system [1,2].Previous phytochemical research on this species revealed that C. pilosula contains polyacetylenes, phenylpropanoids, alkaloids, triterpenoids, and polysaccharides [3,4,5,6], which possess multiple biological activities, such as immunity regulation, learning and memory improvement, and nitric oxide inhibition [7,8]
We describe the isolation, structural characterization, and biological evaluation of the mentioned compounds
Pilosula roots was suspended in water and subsequently partitioned with petroleum
Summary
The root of Codonopsis pilosula, known as “Dangshen” in Chinese, has been used in traditional. Considering that the roots of C. pilosula have, as mentioned above, tonic effects, and that Sirtuin 1 (SIRT1) is associated with many diseases related to ageing, the biological evaluation of all the isolated compounds with respect to SIRT1 was conducted [12,13]. In this contribution, we describe the isolation, structural characterization, and biological evaluation of the mentioned compounds.
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