Abstract
Resveratrol (RSV) and quercetin (QRC) modify energy metabolism and reduce cardiovascular risk factors included in the metabolic syndrome (MetS). These natural compounds upregulate and activate sirtuins (SIRTs), a family of NAD-dependent histone deacetylases. We analyzed the effect of two doses of a commercial combination of RSV and QRC on serum fatty acid composition and their regulation of SIRTs 1–3 and PPAR-γ expression in white adipose tissue. MetS was induced in Wistar rats by adding 30% sucrose to drinking water for five months. Rats were divided into control and two groups receiving the two different doses of RSV and QRC in drinking water daily for 4 weeks following the 5 months of sucrose treatment. Commercial kits were used to determine serum parameters and the expressions of SIRTs in WAT were analysed by western blot. In MetS rats body mass, central adiposity, insulin, triglycerides, non-HDL-C, leptin, adiponectin, monounsaturated fatty acids (MUFAs), and nonesterified fatty acids (NEFAs) were increased, while polyunsaturated fatty acids (PUFAs) and HDL-C were decreased. SIRT 1 and SIRT 2 were downregulated, while PPAR-γ was increased. RSV + QRC administration improved the serum health parameters modified by MetS and upregulate SIRT 1 and SIRT 2 expression in white abdominal tissue in MetS animals.
Highlights
Metabolic Syndrome (MetS) is a complex and heterogeneous disease which is considered as an epidemic
In a MetS model developed by our group, we have found alterations in serum lipid composition, that is, high levels of nonesterified fatty acids (NEFAs) and of monounsaturated fatty acids (MUFAs) which have been proposed as contributors of the acquisition of insulin resistance and hypertension [2,3,4]
Experimental animals developed MetS characterized by hypertension, central adiposity, hyperinsulinemia, and insulin resistance (HOMA-IR)
Summary
Metabolic Syndrome (MetS) is a complex and heterogeneous disease which is considered as an epidemic. MetS groups several cardiometabolic risk factors including abdominal obesity, hyperglycemia, dyslipidemia, insulin resistance, inflammation, and high blood pressure which predispose to the development of type-2 diabetes and cardiovascular diseases [1]. Several factors are involved in the development of MetS which are linked to adipose tissue dysfunction, one of them being the circulating free fatty acids (FFA). In a MetS model developed by our group, we have found alterations in serum lipid composition, that is, high levels of nonesterified fatty acids (NEFAs) and of monounsaturated fatty acids (MUFAs) which have been proposed as contributors of the acquisition of insulin resistance and hypertension [2,3,4].
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