Abstract
Two new triterpenoid saponins (oleanolic acid 2β-hydroxyl-3-O-β-D-glucuronopyranoside-6’-O-buthyl ester (1) and oleanolic acid 2β-hydroxyl-3-O-[β-D-glucuronopyranosyl-6′-O-methylester]-28-O-β-D-glucopyranoside (2)) and two new goodyerosides (4-methylenefuran-2(5H)-one (6′-O-vanilloyl)-β-D-glucopyranoside (3), 3-hydroxy-2(5H)-furanone, 4-(6′-O-vanilloyl)-β-D-glucopyranoside (4)), together with seven known compounds (5–11) were isolated from the whole plant of Tournefortia sibirica L. The chemical structures of the compounds were determined by spectroscopic analysis (1D and 2D NMR) and HR-ESI-MS. Compounds 1, 6 and 9 showed significant cytotoxicity towards A549, SK-Hep1 and HeLa cells, with IC50 values ranging from 1.68 ± 0.09 to 6.87 ± 0.13 μM.
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