Abstract
Two new 9,19-cycloartane triterpene glycosides 1-2, together with four known compounds—26-deoxyactein (3), actein (4), 7,8-didehydro-26-deoxyactein (5) and cimiaceroside B (6)—were isolated from the rhizome of Cimicifuga foetida. The new triterpene glycosides were identified as 23-O-methyl-24-deoxy-2'-O-(3''-methylmalonyl)-cimiaceroside B (1) and 2'-O-(3''-methylmalonyl)actein (2) based on analysis of their spectral data and chemical reactions.
Highlights
Cimicifuga species are popular Chinese Traditional Medicine, and they are widely used as a herbal dietary supplement for the relief of symptoms related to menopause [1,2] with a clinical history going back over forty years [3] in the United States and the European Union
In our continuing to search on C. foetida from different geographic regions, we have separated more than 40 triterpene glycosides [5,6,7,8,9,10,11]
In the present investigation on C. foetida collected in Lijiang county, Yunnan Province, two new glycosides 1-2, besides the known compounds 26-deoxyactein (3) [12], actein (4) [13], 7,8-didehydro-26-deoxyactein
Summary
Cimicifuga species are popular Chinese Traditional Medicine, and they are widely used as a herbal dietary supplement for the relief of symptoms related to menopause [1,2] with a clinical history going back over forty years [3] in the United States and the European Union. Molecules 2011, 16 revealed that triterpene glycosides were the main active components and could be used as marker compounds to standardize the extracts [4]. In our continuing to search on C. foetida from different geographic regions, we have separated more than 40 triterpene glycosides [5,6,7,8,9,10,11]. In the present investigation on C. foetida collected in Lijiang county, Yunnan Province, two new glycosides 1-2, besides the known compounds 26-deoxyactein (3) [12], actein (4) [13], 7,8-didehydro-26-deoxyactein (5) [14] and cimiaceroside B (6) [15] were isolated from it (Figure 1). This report describes the isolation and structure elucidation of the new compounds
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