Abstract
Two new quinolone alkaloids, superbusines A (1) and B (2), were obtained from the whole plants of a Chinese medicinal plant, Dianthus superbus var. superbus. Their structures, featuring a glucosyl moiety linked with a rare 2-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)phenol fragment, were determined on the basis of detailed spectroscopic analyses, and the absolute configurations were assigned by time-dependent density functional theory (TD-DFT)-based electronic circular dichroism (ECD) calculations. The two alkaloids were evaluated in a series of bioassays without showing antimicrobial, anti-inflammatory, antioxidant, cytotoxic and α-glucosidase inhibitory properties, while they exhibited slight protection against amyloid-β(Aβ)-induced injury on neuron SH-SY5Y cells.
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