Two new polyketides isolated from a diethyl sulphate mutant of marine-derived Penicillium purpurogenum G59

Abstract

Two new polyketides, purpurofuranone (1) and purpuropyranone (2), were isolated along with the known polyketides, cillifuranone (3) and taiwapyrone (4), from a mutant BD-3n-1 derived from the diethyl sulfate (DES) mutagenesis of a marine-derived Penicillium purpurogenum G59. The structures of 1 and 2 were elucidated by spectroscopic methods especially on the basis of X-ray diffraction and calculated optical rotations data. The plausible biosynthesis of 1 − 4 was also proposed and discussed. In preliminary MTT assay, 1 − 4 showed no notable inhibitory effects on the tested four human cancer cell lines.