Abstract
Combretum paniculatum, a deciduous tree from the Combretaceae family, has been traditionally used in ethnomedicine for treating conditions such as chronic diarrhoea, dysentery, stomach pain, and wounds. The research aimed to analyse the plant’s chemical composition and its effectiveness against microbial infections. Two compounds were isolated from the plant’s stem barks and identified as cholest-5-en-3-ol and dihexyldecyl succinate, with the latter being newly discovered within the Combretum genus. Both isolated compounds and the plant’s crude extracts were tested against bacteria and fungi. While the isolated compounds showed moderate antibacterial and minimal antifungal activities, the crude extracts displayed superior antimicrobial effects, likely due to the synergistic interactions among multiple compounds. These results suggest potential for further exploration of C. paniculatum’s chemical constituents and their application in treating microbial diseases within the traditional medicine framework.
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