Two mixed-ligand Cu(II) coordination polymers: protective effect on sepsis by reducing an excessive inflammatory response

Abstract

By the reaction of a rigid π-conjugated H4L linker (5,5'-(1,3,6,8-tetraoxobenzo[lmn][3],[8]phenanthroline-2—7-diyl)bis-1,3-benzenedicarboxylic acid), Cu(NO3)2, and N-donor auxiliary linkers, two new Cu-based coordination polymers (CPs), namely {[Cu(L)0.5(1,4-bib)(H2O)2]·0.5H2O}n (1) and {[Cu(H2L)(4,4'-bibp)(H2O)2]}n (2) {1,4-bib = 1,4-bis(1-imidazolyl)benzene, 4,4'-bibp = 4,4'-bis(imidazolyl)biphenyl} are synthesized under solvothermal conditions and characte­rized. Furthermore, the protective effect of compounds 1 and 2 on the sepsis mice model is evaluated and the related mechanism is explored. Firstly, the CFU counting assay is performed to detect the bactericidal effect of compounds 1 and 2 in vivo. Then, the ELISA assay is conducted to measure the release of interleukin-1β (IL-1β) and interleukin-6 (IL-6) into the plasma after treatment with the compounds.