Two-dimensional Ti3C2Tx MXenes as a catalyst support for the synthesis of 1,4-disubstituted-1,2,3-triazoles via azide-nitroalkene oxidative cycloaddition

Abstract

Two-dimensional transition metal carbides/nitrides: MXenes have become a prime choice for researchers to exploit their outstanding properties for various applications in different fields majorly including energy, health and environment. Interestingly, there are no reports of utilizing 2D materials especially MXenes as a catalyst support for organic transformations. In the present study, we have utilized 2D Ti3C2Tx MXenes as a catalyst support for the synthesis of 1,4-disubstituted-1,2,3-triazoles via azide-nitroalkene cycloaddition for the first time. Reusability of Ti3C2Tx MXene catalyst up to five cycles without the loss of catalytic activity with appreciable yields of the product is the noteworthy feature of the present protocol. The synthesized 1,2,3-triazole derivatives possessing long alkyl chain upto fourteen carbon atoms on terminal nitrogen in triazole ring could become a good precursors to give a liquid crystalline properties beyond its biological properties. Nontoxic catalyst, catalyst reusability, broad substrate scope, and good yield are some of the salient features of the present protocol.