Abstract
Two Cases of Sinonasal Teratocarcinosarcoma: Confounders, Treatment and Review of the Literature
Highlights
Combining the histopathological features of carcinosarcoma and malignant teratomas, Sinonasal Teratocarcinosarcomas (SNTCS) are rare, aggressive tumors of the anterior skull base and sinonasal cavity
Sinonasal Teratocarcinosarcomas (SNTCS) are rare tumors of the anterior skull base that are typically diagnosed in the fifth decade of life, with only 5 reported cases in children
We present two cases of SNTCS, one involving a 70-year-old male and one involving a 16-year-old male, the latter having the first endoscopic-only resection of this skull base tumor
Summary
Combining the histopathological features of carcinosarcoma and malignant teratomas, Sinonasal Teratocarcinosarcomas (SNTCS) are rare, aggressive tumors of the anterior skull base and sinonasal cavity. We present two cases of SNTCS, one involving a 70-year-old male and one involving a 16-year-old male, the latter having the first endoscopic-only resection of this skull base tumor. Both of these cases demonstrate successful use of both adjuvant radiation and chemotherapy. After receiving a conclusive diagnosis and discussion at the weekly tumor board, the patient was taken to the OR for complete endoscopic resection of disease with negative margins. Post-operatively, the patient did not develop a CSF leak or any neurologic issues He was treated with four cycles of chemotherapy with doxorubicin, ifosfamid and mesna and 6 weeks of radiation therapy during the second chemotherapy cycle. He remains disease free on exam and surveillance imaging, and has appropriate neurocognitive functioning
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