TWO CASES OF BREAST CANCER ASSOCIATED WITH VON RECKLINGHAUSEN'S DISEASE

Abstract

Two cases of breast cancer associated with von Recklinghausen's disease are reported. Case 1: A 58-year-old woman was admitted to the hospital because of a palpable right breast tumor in March 1986. The tumor, 2.5×2cm in size, was located in C portion of the right breast. Preoperative staging was considered as T2a, N0, M0, and Stage II. Simple mastectomy was carried out, and its histological diagnosis was squamous cell carcinoma. Case 2: A 32-year-old woman was admitted to the hospital because of a left breast tumor in September 1990. The tumor was 2×2cm in size locating in D portion of the left breast, and preoperative staging was T1, N0, M0, and Stage I. Quadrantectomy of mammary gland with axillaly lymph node cleaning (Glp+Ax) was carried out. Histologically it was solid carcinoma. In both cases, there were some neurofibromas and cafe au lait spot like pigmentations of the skin in the neck and the chest. Among 17 cases reported in Japan, their preoperative stagings were more than Stage II except only two cases in Stage I. It was considered that the detection of the breast cancer associated with von Recklinghausen's disease was often delayed because of the neiboring locations of both lesions.