Abstract
As part of the NASA Twins Study, our investigations related to telomeres and DNA damage responses (genome stability) during long-duration spaceflight have important implications for the health and performance of astronauts participating in exploration missions, as well as for long-term aging and disease risk outcomes. Together with the other Twins Study investigations, results will guide future studies and development of personalized medicine approaches for evaluating health effects for individual astronauts as we make our way back to the moon and beyond. Particularly as the number and diversity of space travelers and even space tourists increases over the coming years, identifying individual differences in response to the extreme environment, experiences and chronic exposures associated with space travel, exploration, and eventual habitation of other planets, represents a critical next step for ensuring future astronaut performance and health during, and improving disease and aging courses following, such missions. Ad astra!
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