Abstract
Twenty Five Years of Drug Discovery at the University of California Targeting Kinetoplastid Parasites
Highlights
The three major kinetoplastid parasites are Trypansoma brucei, Trypanosoma cruzi, and Leishmania spp
This review summarizes 25 years of screening compounds against three major kinetoplastid parasites, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp
As similar screening efforts against other molecular targets or with other compound libraries are ongoing, one conclusion is that the current bottleneck in drug development for neglected tropical diseases is downstream of compound screening and hit to lead
Summary
The three major kinetoplastid parasites are Trypansoma brucei, Trypanosoma cruzi, and Leishmania spp. This review summarizes 25 years of screening compounds against three major kinetoplastid parasites, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. Three approaches to discovery of new drugs for kinetoplastid diseases are presented. These include structure-based drug design against specific parasite molecular targets, repurposing of already approved drugs, and screening of marine natural products.
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