Abstract
• Combined addition of TPC2-A1-N and TPC2-A1-P increases the permeability for Ca2+ions of two-pore channel 2 (TPC2). • TPC2 can be tuned to more rapid and larger Ca2+ signals by combined stimulation of TPC2 using TPC2-A1-N and TPC2-A1-P. • Mechanism of action of TPC2-A1-N needs clarification regarding cytosolic NAADP receptor proteins.
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