Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. II. Further consideration of the role of aniline and of the manufacture of auramine and magenta (fuchsine) as possible causative agents.

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In a previous communication (Part I) on occupa tional bladder tumours (Case, Hosker, McDonald, and Pearson, 1954), the primary object was to consider the statistical evidence which had been collected about the manufacture and use of the dyestuff intermediates aniline, benzidine, a naphthylamine, and ?-naphthylamine, and their relation to occupational tumours of the urinary bladder. It was concluded that aniline manufacture and use were probably not a cause of the disease, but that certain aniline workers who were employed in the manufacture of magenta (fuchsine) might be in some danger of developing occupational bladder tumours. At the same time it was suggested that the manufacture of auramine might also be a source of danger, and arrangements were made for a more detailed investigation of the occurrence of bladder tumours in workmen exposed to the manufacture of magenta, in which process aniline is necessarily used, and the manufacture of auramine, where aniline is not used. This investigation, being part of the A.B.C.M. Papilloma Research Scheme (Association of British Chemical Manufacturers, 1953), was of necessity confined to the same firms as had hitherto been investigated and the data relate only to the manu facture of magenta and auramine. These substances differ from the other substances so far studied