Abstract
One of the major reasons for the non-effectiveness of anticancer therapeutics designed to target tumour angiogenesis is the involvement of multiple layers of cellular communication that exists within the tumour microenvironment. Any attempt to block one signaling pathway by targeting one of its components led to the activation of alternate pathway that overcome this block rendering the therapy ineffective. During the previous decades most of the research was focused on manipulating signaling pathways initiated by soluble factors and their intermediates. More recently the work from our lab and many advanced labs all over the globe have brought into light, the significance of signaling events mediated by exosomes in regulation of tumour progression and angiogenesis. In this mini review we intend to collate the information available from several groups including ours related to the role of exosomal cargo especially exosomal miRNAs in modulating tumour angiogenesis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
