Abstract
Microbubbles based contrast-enhanced ultrasound plays a more and more important role in oncology1. However, the utility of ultrasound for molecular imaging is significantly limited due to the lack of nanoscale contrast agents that can penetrate through tumor vasculature via the Enhanced Permeability and Retention (EPR)effect2. Recently reported gas vesicles (GVs), isolated from buoyant photosynthetic microbes, demonstrated significant potentials as a novel nanoscale contrast agent for ultrasound molecular imaging3-4. However, the actual capability of GVs to penetrate through EPR and reach tumor site has not been demonstrated. In this research, we evaluated the bio-distribution of GVs in subcutaneous mouse tumor model with in vivo fluorescence imaging and ultrasound imaging, respectively, and studied the GV s biosafety by tissue toxicity assessment.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
