Abstract
BackgroundPrognosis is poor for patients with malignant progression such as distant metastasis of oral squamous cell carcinoma (OSCC). Evidence indicates that miR-448 promotes the proliferation and inhibits apoptosis of OSCC cells. Therefore, we aimed to investigate the function of miR-448 to predict tumor progression and prognosis of OSCC.MethodsReal-time quantitative reverse transcription PCR was used to measure miR-448 expression in 221 pairs of OSCC tissues and the corresponding noncancerous tissues. Patients were diagnosed with OSCC from 2009 through 2011 at the Tianjin Medical University Cancer Institute and Hospital. Chi-squared tests were performed to assess the associations between miR-448 expression and clinicopathological parameters. Kaplan–Meier analysis was employed to evaluate the association of overall survival (OS) and disease-free survival (DFS) with miR-448 levels. Univariate and multivariate analyses were performed using the Cox proportional hazards regression model.ResultsWe show here that miR-448 expression was significantly up-regulated in OSCC tissues compared with noncancerous tissues (P < 0.01). High miR-448 expression was significantly associated with advanced T stage (P = 0.001), lymph node metastasis (P = 0.007) and higher TNM stage (P = 0.009). Moreover, Kaplan–Meier and univariate analyses revealed that patients with high expression of miR-448 experienced significantly shorter OS and DFS. Furthermore, multivariate analysis demonstrated that miR-448 expression was an independent prognostic factor for OS (P = 0.004) and DFS (P = 0.002).ConclusionsOur present data suggests that miR-448 may play an important role in tumor progression and serves as a prognostic marker for OSCC. Further studies are required to assess the potential value of miR-448 to contribute to personalized treatment of OSCC.
Highlights
Prognosis is poor for patients with malignant progression such as distant metastasis of oral squamous cell carcinoma (OSCC)
MiR-448 is overexpressed in OSCC We used Quantitative reverse transcription PCR (qRT-PCR) to investigate miR-448 expression in 221 pairs of OSCC tissues and the corresponding noncancerous tissues
MiR-448 levels were significantly higher in OSCC tissues than in adjacent non-neoplastic tissues (P
Summary
Prognosis is poor for patients with malignant progression such as distant metastasis of oral squamous cell carcinoma (OSCC). We aimed to investigate the function of miR-448 to predict tumor progression and prognosis of OSCC. At least 90% of oral cancers originate from squamous cells and are designated as oral squamous cell carcinoma (OSCC) [2]. Despite continuous advances in treatment strategies and diagnostic methods, the incidence and mortality rates associated with OSCC are increasing [3, 4]. Prognosis is worse for patients with OSCC with malignant progression such as distant metastasis [7]. It is necessary to find effective biomarkers to predict tumor progression and prognosis to provide personalized treatment
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