Abstract

Objective To analyze the expressions of TGF-β1, Smad4, and Smad7 in the tissure of oral squamous cell carcinoma (OSCC) and its relationship with the clinical features of OSCC, to further explore the roles of TGF-β1/Smad4 or Smad7 signaling pathways in the formation and development of OSCC, and to provide a theoretical basis for the diagnosis and treatment of OSCC. Methods 62 patients with OSCC treated at our hospital from March, 2013 to February, 2016 were collected. The specimens of OSCC and adjacent normal mucosa tissue were collected. The expressions of TGF-β1, Smad4, and Smad7 in the specimens were determined by immunohistochemical method. The relationship between them and the clinical features of OSCC was analyzed. Results The positive expression rates of TGF-β1 and Smad7 were significantly higher and the positive expression rate of Smad4 was significantly lower in OSCC tissue than in adjacent normal mucosa tissue (P < 0.05) . The positive expression rates of TGF-β1 and Smad7 in OSCC increased with the pathological grade of OSCC and with the decrease of OSCC differentiation. The positive expression rates of TGF-β1 and Smad7 were significantly higher in the patients with lymph node metastasis than in the those without (P<0.05) . The positive expression rate of Smad4 decreased with the increase of OSCC pathological grade and with the degree of the differentiation of OSCC; and that of the patients with lymph node metastasis was significantly lower than that that of those without (P < 0.05) . Spearman correlation analysis showed that the expression of TGF-β1 in OSCC negatively correlated with the expression of Smad4 (P < 0.05) and positively with the expression of Smad7 (P < 0.05) . Conclusions TGF-β1 and Smad7 highly expressed and Smad4 low in OSCC tissues. Therefore, the combined detection of them may be helpful for the diagnosis and treatment of OSCC. Key words: Transforming growth factor; Smad; Oral squamous cell carcinoma

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