Tumor cell membrane-coated biomimetic nanoplatform for homologous targeted therapy of colorectal carcinoma

Abstract

To avoid the clearance of reticuloendothelial system (RES) and realize tumor-specific targeting drug delivery are still the main challenges for nanodrug delivery systems in treatment of tumor. Recently, cell membranes coated nanoparticles have garnered more and more attention because of their mimic ability with their source cells, which are very effective in tumor therapy. Herein, we fabricated a biomimetic nanodrug delivery system composed of paclitaxel (PTX)-loaded gelatin nanogels (GN) as the inner cores and HT-29 tumor cell membranes (TCMs) as the outer shells, noted as TCM/GN/PTX for the targeted therapy of colorectal carcinoma. The TCM/GN/PTX showed obvious core-shell nanostructure and effectively reduced the release of laden PTX. Due to the homotypic targeting ability of coated TCM, the TCM/GN/PTX could realize the selective targeting of the homotypic tumor cells, therefore, obviously improving the accumulation of PTX at tumor sites. After administration in HT-29 xenografts mouse models, the TCM/GN/PTX significantly suppressed the tumor growth by inducing the necrosis and apoptosis of tumor cells. Moreover, due to the coated TCM effectively avoided the premature release of PTX, the TCM/GN/PTX showed minimal side effects. As a result, this bioinspired strategy-based biomimetic platform can be a promising nanodrug delivery system for unique targeted therapy of colorectal carcinoma.