Abstract
Association of immune thrombocytopenic purpura and tuberculosis is a rare condition. In 5 patients presenting with this association, anti-tuberculous therapy was effective on both tuberculosis and thrombocytopenia suggesting a causal relationship between tuberculosis and immune thrombocytopenic purpura
Highlights
Immune thrombocytopenic purpura (ITP) is characterized by a low platelet count associated with the presence of platelet autoantibodies
We describe 5 cases of the association of tuberculosis and ITP and the effectiveness of anti-tuberculous therapy (ATT) on both tuberculosis and thrombocytopenia (Figure 1)
No patient was cured at the time of tuberculosis diagnosis or within the month following the onset of ATT
Summary
Immune thrombocytopenic purpura (ITP) is characterized by a low platelet count associated with the presence of platelet autoantibodies. The diagnosis of ITP remains a diagnosis of exclusion, and a bone marrow examination should be performed in patients with atypical features. In 5-10% of cases, ITP is associated with chronic infection (HIV, HCV), systemic autoimmune disorders, lymphoproliferative disorders, and primary immunodeficiency. ITP is usually chronic (i.e. more than six months in duration).[1] The response to treatment is defined as an increase in platelet count above 50×109/L, with at least a 2-fold increase in the initial value and remission is considered if platelet count reaches 150×109/L.2. We describe 5 cases of the association of tuberculosis and ITP and the effectiveness of anti-tuberculous therapy (ATT) on both tuberculosis and thrombocytopenia (Figure 1)
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