Abstract
Atopic dermatitis (AD) is a chronic disease affecting 10–30% of children and 2–10% of adults worldwide. It is manifested by the pruritus eczema lesions on the skin. Immune thrombocytopenic purpura (ITP) is the most common cause of acute onset of thrombocytopenia in childhood. The aim of this study was association of primary immune thrombocytopenic purpura and atopia among children. This case control study was performed on patients with acute and chronic ITP who were confirmed by a hematologist. The control group was also selected from the siblings of the patients who were healthy and almost matched by age and sex with the patient group. Data were entered into a questionnaire under the SPSS-20 program, and demographic data were analyzed descriptively. In the present study, 120 patients were enrolled, 60 of whom were in the patient group and 60 in the control group. Mean age was 95 and 98 months for patients and control. This study showed a significant association of ITP with allergic rhinitis (P = 0.02), atopic dermatitis (P = 0.004), itching (P = 0.042), and dry skin (P = 0.015). However, no significant relationship was found between ITP and asthma (P-value = 0.18). This study does not reveal the causality between atopy and ITP but clearly shows the association between atopy and ITP disease, so the prevalence of atopy in ITP patients is higher than the normal population. According to the results of this study, it is necessary to investigate the cause of atopy and ITP and to find other immunological and possibly genetic commonalities.
Highlights
Atopic dermatitis (AD) is a chronic disease affecting 10–30% of children and 2–10% of adults worldwide
Regarding the association between asthma and Immune thrombocytopenic purpura (ITP) in the patient and control groups, the results showed that, only 4 cases (6.3%) had asthma in the patient group and 56 cases (93.7%) did not have asthma
Conjunctival disorders in patients with ITP is more likely than control group (P = 0.05) (Table 2)
Summary
Atopic dermatitis (AD) is a chronic disease affecting 10–30% of children and 2–10% of adults worldwide. The aim of this study was association of primary immune thrombocytopenic purpura and atopia among children This case control study was performed on patients with acute and chronic ITP who were confirmed by a hematologist. The main treatment for the disease is topical corticosteroids, which are prescribed based on the severity of the lesions with low, moderate or severe p otency[11] Atopic disorders such as allergic conjunctivitis, asthma, allergic rhinitis can occur in other diseases such as Immune thrombocytopenic purpura (ITP). ITP is clinically common with petechia, purpura, and mucosal bleeding that usually results from an upper respiratory tract infection[14] It manifests itself in the majority of affected children with acute self-limitation up to 12 months, with or without treatment, and eventually the platelet count returns to n ormal[15,16]. Given the immunological abnormalities in the pathophysiology of both diseases, the association of both diseases with allergic diseases, and the presence of genetic risk factors in both diseases, we aimed to investigate the relationship between these two disorders in terms of epidemiology and clinical manifestations of atopy
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