Abstract
G A A b st ra ct s increase of CD11c+ cells in the lamina propria of which are 90% CD11b+ and 40% β2-AR positive. Conclusion: Stimulation of the β2-AR expressed by BMDC results in a significant anti-inflammatory cytokine profile compared to the inflammatory phenotype with high levels of IL-12p70, IL-6, TNFα and low IL-10 of vehicle treated BMDC. In T cell dependant colitis there is a significant increase of CD11c+CD11b+ DC in the lamina propria which express the β2-AR. Treating IBD patients with β2-AR agonists might have the same effect on inflammatory DC as in BMDC and could potentially ameliorate disease activity.
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