Tu1614 Abdominal Compression During Endoscopy (the Bolster Technique) Demonstrates Hidden Schatzki Rings

Abstract

procedure and did not have significant clinical pathology. There was 50% incidence of esophageal stricture in the 180 EMR group, and 100% in the 270 and 360 EMR groups. The strictures in non-stented Yorkshire pigs with 270 EMR peaked by 4 wk. (w50% reduction in esophageal lumen diameter), while the lumen reduction in non-stented animals with 360 EMR was O 80% by 2 weeks requiring euthanasia per protocol. In Yucatan swine, the reduction in lumen diameter peaked by 3 wk (w70%) for both 270 and 360 EMR groups. In general, mild mucosa/submucosa fibrosis was observed in Yorkshire pigs at all evaluated time points and often extended into the muscularis externa. Moderate to severe mucosa/submucosa fibrosis was observed in Yucatan pigs at 6 wk., with no pathology in the muscularis externa. There was 33% (1/3) and 66% (2/3) stent migration into the stomach in 360 and 270 EMR stented-animals, respectively. Conclusion: Both swine models demonstrated a reproducible reduction in esophageal lumen diameter with O 270 degree EMR. However, controlled rate of skeletal growth is a key feature for long-term studies; therefore the Yucatan is the recommended model. We demonstrated reduced stent migration in the Yorkshire model compared to historical data in naive animals. EMR-induced stricture models are more suitable than naive swine to evaluate esophageal stent